Basic Information
VIS ID
TVIS20003377
Fusion event
HPV-PLEKHG1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
151005646/150684510 (Hg38)
End
151005646/150684510 (Hg38)
Location type
Intronic
Target gene
PLEKHG1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-498
Nearest miRNA
hsa-mir-10398/Upstream/10000627; hsa-mir-1202/Downstream/418165;
Nearest TSS
ENST00000381078/Upstream/898; ENST00000644913/Downstream/2252;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/83500, chr6-CpG: 133/Downstream/181250
Upstream sequence
aaatgggagtttccctacacacgctctcttctcttgtctggcctccctagccatgtggaactgaaggtccaataaacctccttcttttgtaaattgctca
Downstream sequence
GCTGTGCAGGGGTTTCAGTGTCTGAATTTGGGCAGTTTGCTGTGCTTCCGAAATGGTTCTGGCCAACCCTGTGTCTCCCCTTGGACTTCTGATTGGCCCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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