Basic Information
VIS ID
TVIS20003385
Fusion event
HPV-MTOR integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
11168498/11108441 (Hg38)
End
11168498/11108441 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MTOR
miRNAs that regulate target gene
hsa-mir-99a-5p ; hsa-mir-520c-3p ; hsa-mir-373-3p ; hsa-mir-99b-5p ; hsa-mir-144-3p ; hsa-mir-100-5p ; hsa-mir-199a-3p ; hsa-mir-16-5p ; hsa-mir-744-5p ; hsa-mir-181b-5p ; hsa-mir-101-3p ; hsa-let-7c-5p ; hsa-mir-218-5p ; hsa-mir-496 ; hsa-mir-196b-5p ; hsa-mir-224-5p ; hsa-mir-128-3p ; hsa-mir-193a-5p ; hsa-mir-125a-5p ; hsa-mir-497-5p ; hsa-mir-3188
Nearest miRNA
hsa-mir-12136/Upstream/1140983; hsa-mir-101-1/Downstream/920717;
Nearest TSS
ENST00000473358/Upstream/8560; ENST00000445982/Downstream/6188;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/8362, chr1-CpG: 60/Downstream/153760
Nearest cancer related gene
MTOR(OG, No orient, 0)
Upstream sequence
TGACCTGGTGCCTCCCCCAACCCTCTTTATGTCTCCCATGTTCCCCCACTTTTTTTTTGTTTGTTTTACCTTTCTAGCCCATCATTTCTGACATTCTCTA
Downstream sequence
CTTCCCCTGTTAATACCTGTGTTGAGTTCCATTGCCCAGGGCTCTGCCAGGTGATTGACTGTATTAGACAATTTGTAGCAAACCTGTTGATAGCCTACAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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