Basic Information
VIS ID
TVIS20003392
Fusion event
HPV-CCDC88B integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64119232/64351760 (Hg38)
End
64119232/64351760 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
CCDC88B
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-129-2/Upstream/9856; hsa-let-7a-2/Downstream/16842;
Nearest TSS
ENST00000527297/Upstream/2929; ENST00000473405/Downstream/1126;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/9004, chr11-CpG: 62/Downstream/7198
Upstream sequence
CCACCAacacatgcacacacacgcacactgcacacacagtacacacacacacacaccacatatacacaccatactcacgccacacacacaccacacacca
Downstream sequence
cacacatacacaccacacacaccacacacataccacacacacaccatacaaactacacacaccacacaatacgtgcacacacacgccacacaaacccacc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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