Basic Information
VIS ID
TVIS20003397
Fusion event
HPV-UGGT2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
96479620/95827366 (Hg38)
End
96479620/95827366 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
UGGT2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-218-5p ; hsa-mir-1247-3p ; hsa-mir-1976 ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4532 ; hsa-mir-4722-3p ; hsa-mir-484 ; hsa-mir-5571-5p ; hsa-mir-6715b-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6752-3p ; hsa-mir-6778-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6836-3p
Nearest miRNA
hsa-mir-1297/Upstream/3337146; hsa-mir-1267/Downstream/599863;
Nearest TSS
ENST00000623511/Upstream/150208; ENST00000620595/Downstream/32529;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/149674, chr13-CpG: 81/Downstream/225609
Upstream sequence
AATATGTAATAAATTTCAATTACTTGTAAGTGAAACAATTGCATGACAACAATTCTAATATTTTTTCAACATATTCAGTTTTACATTTGTAGGGATTTGT
Downstream sequence
TTGTTTCAACTACATTAGTAATAAATTATCAAGCTTTTTTTCTCTGACCCCTGATTTCAGCTTTGCCATTTTTCCTCTGTCACTTAAGGTATCTATAATT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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