Basic Information
VIS ID
TVIS20003406
Fusion event
HPV-L3MBTL4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
5964540/5964541 (Hg38)
End
5964540/5964541 (Hg38)
Location type
Intronic
Target gene
L3MBTL4
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-3976/Upstream/123708; hsa-mir-1-2/Downstream/409820;
Nearest TSS
ENST00000575820/Upstream/8440; ENST00000577935/Downstream/60550;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/68291, chr18-CpG: 22/Downstream/319834
Nearest cancer related gene
L3MBTL4(TSG, No orient, 0)
Upstream sequence
ttttcttCGGACCCCTCTGAAACGTTCAGTGTTGAAAAGCTGTCTACTTACTCTCCCCTCCTGCCTGAAGTCTGAGTTTCTCTTCAGTAGGAGACACTTG
Downstream sequence
GCTGCTCTGCTTATGAGCAATACCCCGAATTTTTCAAATCACCCCTTCCTGTGTAAAGGCTGCTTTTAAAGTGACTGCCATCTTTCAAAGTTAATGAACA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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