Basic Information
VIS ID
TVIS20003414
Fusion event
HPV-CRYBA2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
219856374/218991652 (Hg38)
End
219856374/218991652 (Hg38)
Location type
Intronic
Target gene
CRYBA2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10b/Upstream/168498; hsa-mir-1244-1/Downstream/9993;
Nearest TSS
ENST00000437798/Upstream/156; ENST00000441450/Downstream/1526;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/5863, chr2-CpG: 122/Downstream/1308
Upstream sequence
catgccattcccttggtatgtttaatgtatctctgtggatgtggatggagccttaaaagagatatgatactgtgtatgtgtgtattgaatttacagaaat
Downstream sequence
AACACCCTCACACACACAATAACACACACACAAACACACTGAGACTGACTCTTTTCAgtgaccctgggcaagccactttgtccctttgagccccatttcc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate