Basic Information
VIS ID
TVIS20003418
Fusion event
HPV-FBLN2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
13660310/13618810 (Hg38)
End
13660310/13618810 (Hg38)
Location type
Intronic
Target gene
FBLN2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4775 ; hsa-mir-32-3p ; hsa-mir-548at-5p ; hsa-mir-497-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-12127/Upstream/3224248; hsa-let-7g/Downstream/1877429;
Nearest TSS
ENST00000440867/Upstream/4912; ENST00000295761/Downstream/12519;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/47875, chr3-CpG: 21/Downstream/18757
Upstream sequence
cttccaacactataaagggttttctattcccctacttccttttgagtcttcaccagccacatgtgatgatggctgccacccttgttctagaaagcccaga
Downstream sequence
CTGTGTGAGAAGGGCAGGTGCCTGGAAGTGCCTGAGGCCTGGCTGAAGACCTGAGACCTCCCTGCAACCCCCACTCTGCTCTACCCATGACAGAGGGTCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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