Basic Information
VIS ID
TVIS20003421
Fusion event
HPV-TET2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
106089512/105168355 (Hg38)
End
106089512/105168355 (Hg38)
Location type
Intronic
Target gene
TET2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-484 ; hsa-mir-92a-3p ; hsa-mir-22-3p ; hsa-mir-101-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-26a-5p ; hsa-mir-5011-5p ; hsa-mir-7-5p ; hsa-mir-125b-5p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4775 ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-12113/Upstream/3837941; hsa-mir-1243/Downstream/4320343;
Nearest TSS
ENST00000502981/Upstream/20898; ENST00000265154/Downstream/9708;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/21544, chr4-CpG: 82/Downstream/305039
Nearest cancer related gene
TET2(TSG, No orient, 0)
Upstream sequence
TTAGACCCCACTACAGTGGAAGCTTGTAGAACATCACACATCGACAGTCTGAAATGCACCACAAGAACTGCTCGAAGAGTGTGTCACTTTCACACTTACC
Downstream sequence
ttcttgctgtcctggcaacaagaagagcatcctttttcctccaggcctttgcacttgctgttccctcttcctggagcacccttccttcagagagccacag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate