Basic Information
VIS ID
TVIS20003425
Fusion event
HPV-FSTL4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
133036071/133700380 (Hg38)
End
133036071/133700380 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
FSTL4
miRNAs that regulate target gene
hsa-mir-3691-5p ; hsa-mir-432-3p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-1193 ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4472 ; hsa-mir-3175 ; hsa-mir-4447 ; hsa-mir-6878-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-7515 ; hsa-mir-194-3p ; hsa-mir-1296-3p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-4662b ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4742-3p ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-7856-5p ; hsa-mir-4503 ; hsa-mir-6792-5p
Nearest miRNA
hsa-mir-10397/Upstream/272674; hsa-mir-103a-1/Downstream/525377;
Nearest TSS
ENST00000502646/Upstream/87816; ENST00000513561/Downstream/213297;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/87604, chr5-CpG: 36/Downstream/267915
Upstream sequence
GTAAAGATAAAAGAACTGTAGAGTGCTCCtgatatggtttggctgtgtcctcatccagatctcatcttgaattgtaattcccataatcctcacatgtcat
Downstream sequence
ccaaacaccacaccaaaccatcagaccaaagcaccacaccaaaccatcacaccaaacaccacaccaaaccatcacaccaagccaccacaccaaaccacCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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