Basic Information
VIS ID
TVIS20003427
Fusion event
HPV-CTNNA1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
HQ537777.1
Host Sequence
Chromosome
chr5
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
138230753/138895064 (Hg38)
End
138230753/138895064 (Hg38)
Location type
Intronic
Target gene
CTNNA1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-744-5p ; hsa-mir-296-3p ; hsa-mir-769-3p ; hsa-mir-615-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10397/Upstream/1247415; hsa-mir-103a-1/Downstream/1668607;
Nearest TSS
ENST00000502646/Upstream/8835; ENST00000519489/Downstream/9335;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/140917, chr5-CpG: 43/Downstream/303117
Upstream sequence
gttgttccaacactaccctgaaaagatgatcccttcccttggcttctttgctgaaaatcacttgactacagatacatgaatctactattggaccctctat
Downstream sequence
tactccaaaagaatataagttatctgaggacatgggccaagaatagtacctagaatatagtaggtgctcagcaactactagatgagggaaCCTATtggtt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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