Basic Information
VIS ID
TVIS20003440
Fusion event
HPV-MME integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
154755403/155037614 (Hg38)
End
154755403/155037614 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
MME
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7g/Upstream/3471619; hsa-mir-1224/Downstream/4245032;
Nearest TSS
ENST00000440867/Upstream/13490; ENST00000497890/Downstream/42033;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/608438, chr3-CpG: 60/Downstream/41995
Nearest cancer related gene
MME(TSG, No orient, 0)
Upstream sequence
ttctcactcataggtgggaattgaacaatgtgaacacatggacacaagaaggggaacatcacacacccaggcctgtcctggggtggggggaggggggagg
Downstream sequence
aggaagaactaaggaaggaggctgtaaagaagcaatgagtgaaggaagacaaccgtgagaaggaattgtcccagaaaccagtgaagaaagtgtttcaaga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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