Basic Information
VIS ID
TVIS20003444
Fusion event
HPV-STARD8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
67913974/68694132 (Hg38)
End
67913974/68694132 (Hg38)
Location type
Intronic
Target gene
STARD8
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-125b-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1277-5p ; hsa-mir-4718 ; hsa-mir-656-3p ; hsa-mir-4789-3p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-3675-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-4298 ; hsa-mir-1302 ; hsa-mir-4425 ; hsa-mir-1273g-5p ; hsa-mir-92a-1-5p ; hsa-mir-876-3p ; hsa-mir-323a-5p ; hsa-mir-3649 ; hsa-mir-711 ; hsa-mir-6758-3p ; hsa-mir-205-3p
Nearest miRNA
hsa-let-7f-2/Upstream/2675153; hsa-mir-105-1/Downstream/1328725;
Nearest TSS
ENST00000429181/Upstream/481; ENST00000204961/Downstream/134865;
Nearest CpG islands
chrX-CpG: 79/Target, None/Upstream, None/Downstream
Upstream sequence
ttgtttgcagatgatgtgatcttctatttggaaaaccttaaagactctaccaaaaaactatttgaactgataaattgagtaaaattgcaggatacaaatt
Downstream sequence
GCCGTCGCTCTGGGGCTTTGGAGGGGCGTTGCAGCTGGCCGGGGGCGGCAGAGCTTCAGGCTCTGTTGCCGGGTCGCGCCAGATCTCCTGCCCTCTCCTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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