Basic Information
VIS ID
TVIS20003446
Fusion event
HPV-CELF2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh37/hg19
Start
11011805/10969842 (Hg38)
End
11011805/10969842 (Hg38)
Location type
Intronic
Target gene
CELF2
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-375 ; hsa-mir-324-5p ; hsa-let-7e-5p ; hsa-mir-95-3p ; hsa-mir-4717-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-192-3p ; hsa-mir-124-5p ; hsa-mir-4275 ; hsa-mir-203a-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-642a-5p ; hsa-mir-329-5p ; hsa-mir-4748 ; hsa-mir-4464
Nearest miRNA
hsa-mir-3155a/Upstream/4817565; hsa-mir-107/Downstream/1160918;
Nearest TSS
ENST00000439456/Upstream/9691; ENST00000633200/Downstream/35479;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/703216, chr10-CpG: 158/Downstream/47637
Upstream sequence
TTAATAAAAAAATTTGTTTACCACTTTATATAGTATTAGTTGAGGAAATCATACATCTTCCATGTTTAGCTGTTACTATGTGCTGGTGCCTTTCTCTATT
Downstream sequence
TTTGCATACTGCACAAAAAGCTTCAAAAGGAATCTTTCCTCATTTAATAAATCTCCACTTTTCAAACAATTCATCGCAAAGTATATGCTTGAATTTTGGT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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