Basic Information
VIS ID
TVIS20003466
Fusion event
HPV-CCDC81 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1;EU918767.1
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
86101738/86390696 (Hg38)
End
86101738/86390696 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11F
Target gene
CCDC81
miRNAs that regulate target gene
hsa-mir-6802-3p ; hsa-mir-513b-5p ; hsa-mir-4705 ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-10392/Upstream/112298; hsa-let-7a-2/Downstream/1785806;
Nearest TSS
ENST00000527297/Upstream/15804; ENST00000529603/Downstream/4415;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/15732, chr11-CpG: 25/Downstream/40641
Upstream sequence
TGGTACCTGGcaacactatgatacagtattatcagctgcattgtataaatgaggagatagcagctcagagaggtggagtgatttgcccaaggtcacacag
Downstream sequence
cagtcaagaacagagtcaaaagaggaaccttggtcttctggcttaaatccatgtctcttcccatcacacaaccctgAATCCCATGCACACATTAGCAGGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate