Basic Information
VIS ID
TVIS20003467
Fusion event
HPV-GPATCH8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1;EU918767.1
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
42519604/44442236 (Hg38)
End
42519604/44442236 (Hg38)
Location type
Intronic
Target gene
GPATCH8
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-130b-3p ; hsa-mir-148a-3p ; hsa-mir-19b-3p ; hsa-mir-302c-5p ; hsa-mir-655-3p ; hsa-mir-543 ; hsa-mir-3143 ; hsa-mir-374c-5p ; hsa-mir-3613-3p ; hsa-mir-552-5p ; hsa-mir-2053 ; hsa-mir-569 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6828-5p ; hsa-mir-1183 ; hsa-mir-8084 ; hsa-mir-4506 ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-15a-5p ; hsa-mir-6838-5p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-429 ; hsa-mir-4257 ; hsa-mir-6847-5p ; hsa-mir-5582-5p ; hsa-mir-548an ; hsa-mir-124-3p ; hsa-mir-2355-3p ; hsa-mir-4646-3p ; hsa-mir-4433b-5p ; hsa-mir-7977 ; hsa-mir-4433a-5p ; hsa-mir-545-3p ; hsa-mir-4307 ; hsa-mir-548p ; hsa-mir-33a-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-223-3p ; hsa-mir-4328
Nearest miRNA
hsa-mir-1180/Upstream/234397; hsa-mir-10226/Downstream/492382;
Nearest TSS
ENST00000595228/Upstream/5449; ENST00000315323/Downstream/3686;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/56025, chr17-CpG: 72/Downstream/60773
Upstream sequence
GAAGAGCGGTCTCCCTTCTCCTCCTGCTCCCCCAACAACAACAGTCCGAGGGAAAAAAAGTATGCTCAGCAGGCCTGCACTCCACCTTTATGCCTGCCCC
Downstream sequence
CCGCAGCACCACGTTCCATGAATTACCAATAAATAGGCAAAATAGAGTAATCTGACCAGCTGGAACTTCAGCTGAGAATGAGAGAAAACAGAACATTTGT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate