Basic Information
VIS ID
TVIS20003481
Fusion event
HPV-HPCA integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537688.1;HQ537777.1
Host Sequence
Chromosome
chr1
Cytoband
p35.1
Reference genome
GRCh37/hg19
Start
33353570/32887969 (Hg38)
End
33353570/32887969 (Hg38)
Location type
Intronic
Target gene
HPCA
Nearest miRNA
hsa-mir-12136/Upstream/800962; hsa-mir-101-1/Downstream/444424;
Nearest TSS
ENST00000473358/Upstream/1507; ENST00000470896/Downstream/5555;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1173, chr1-CpG: 84/Downstream/4899
Upstream sequence
CGGTAACTGGGTGGACACTGTACAAGATGGAGATGATGCTGATGGTCTGATGAGGGAAACAGGCCATCCTAAGAAGGTGAGGTCAAACACTTAACCCAGG
Downstream sequence
GACGCAGTTGGCGGAGGGGCAATTACAGGAGACAATGACTTTGAGTACCTCTCAGTTTGGTGACACTCAGATTACCTTCAAAGGAAAATGCTTATAAAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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