Basic Information
VIS ID
TVIS20003499
Fusion event
HPV-PLEC integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
AY262282.1;EU918767.1
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145020556/143946388 (Hg38)
End
145020556/143946388 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
PLEC
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-769-3p ; hsa-mir-615-3p ; hsa-mir-6796-5p ; hsa-mir-7109-5p ; hsa-mir-3978 ; hsa-mir-6790-5p ; hsa-mir-6742-5p ; hsa-mir-4658 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-3151-5p ; hsa-mir-491-5p ; hsa-mir-4792 ; hsa-mir-6842-5p ; hsa-mir-7110-5p ; hsa-mir-6752-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-3659 ; hsa-mir-4487 ; hsa-mir-574-5p ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-875-3p ; hsa-mir-6835-3p ; hsa-mir-1266-5p ; hsa-mir-127-5p ; hsa-mir-1293 ; hsa-mir-1827 ; hsa-mir-1909-3p ; hsa-mir-3174 ; hsa-mir-323a-5p ; hsa-mir-3612 ; hsa-mir-363-5p ; hsa-mir-3664-3p ; hsa-mir-4257 ; hsa-mir-4433a-3p ; hsa-mir-4433b-3p ; hsa-mir-4443 ; hsa-mir-4459 ; hsa-mir-4483 ; hsa-mir-4518 ; hsa-mir-4651 ; hsa-mir-4768-3p ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-608 ; hsa-mir-650 ; hsa-mir-6722-3p ; hsa-mir-6745 ; hsa-mir-6782-5p ; hsa-mir-6804-5p ; hsa-mir-6808-5p ; hsa-mir-6847-5p ; hsa-mir-6854-5p ; hsa-mir-6880-5p ; hsa-mir-6893-5p ; hsa-mir-7847-3p ; hsa-mir-940
Nearest miRNA
hsa-mir-1204/Upstream/1109; hsa-mir-10400/Downstream/110933;
Nearest TSS
ENST00000518652/Upstream/1651; ENST00000530898/Downstream/17;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1342, chr8-CpG: 47/Downstream/3893
Upstream sequence
ATCTTGGAATAATGCTATATCTTAACACTACTTCTGTACTATCTTTTTCTGTGTGTGCATATTTTATAGTTATTTATGTTTATATATGATTACTCAAACA
Downstream sequence
CCATGGCTGCCACACAGGCCAGGCTGCTCCGAGAGCCggcagggaggaaggcgaggcaggaaggagggaaggggtgggaggcagagggagggCCCACTCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate