Basic Information
VIS ID
TVIS20003503
Fusion event
HPV-MORC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
108759197/109040350 (Hg38)
End
108759197/109040350 (Hg38)
Location type
Intronic
Target gene
MORC1
miRNAs that regulate target gene
hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-4423-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-let-7g/Upstream/5516234; hsa-mir-12124/Downstream/562478;
Nearest TSS
ENST00000440867/Upstream/86455; ENST00000480826/Downstream/61106;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/450593, chr3-CpG: 28/Downstream/77598
Upstream sequence
GTTTTCCATGCTTCTCTGGTATTACCCTGTGTTTATATTTCACAGCTCAGTTTTGGCCGCTCCTTCCTCACTCTGTATAATCTTTCTCAGTTATCTCAGT
Downstream sequence
actgaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagagaaggaaggaaggaaggaaggaaggaaagaaagaaagaaagaaagaa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate