Basic Information
VIS ID
TVIS20003533
Fusion event
HPV-MAP3K13 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
185040343/185322555 (Hg38)
End
185040343/185322555 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
MAP3K13
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-203a-3p ; hsa-mir-129-5p ; hsa-mir-153-5p ; hsa-mir-3978 ; hsa-mir-589-3p ; hsa-mir-6760-3p ; hsa-mir-6835-3p ; hsa-mir-7850-5p
Nearest miRNA
hsa-let-7g/Upstream/69283; hsa-mir-1248/Downstream/445292;
Nearest TSS
ENST00000440867/Upstream/37162; ENST00000428617/Downstream/6333;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/39447, chr3-CpG: 71/Downstream/175967
Upstream sequence
cagactatatagaaaaatagaacactgacccaccacctgcagaaaccagtcgaggaaaccacaacttttgcagccatcggccccaaatggttggtactta
Downstream sequence
GGCCGCTCCTTCCTCACTCTGTATAATCTTTCTCAGTTATCTCAGTTCTGTTCTCTcatactgtgtatccagatgccttttggacaattcaactaggaca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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