Basic Information
VIS ID
TVIS20003626
Fusion event
HPV-ARHGAP42 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Cell line
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100637503/100766772 (Hg38)
End
100637503/100766772 (Hg38)
Location type
Intronic
Target gene
ARHGAP42
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-28-5p ; hsa-mir-222-3p ; hsa-mir-138-5p ; hsa-mir-376c-3p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-4299 ; hsa-mir-3692-5p ; hsa-mir-4633-3p ; hsa-mir-6071 ; hsa-mir-6500-5p ; hsa-mir-587 ; hsa-mir-6131 ; hsa-mir-3185 ; hsa-mir-133a-5p ; hsa-mir-93-3p ; hsa-mir-885-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-4511
Nearest miRNA
hsa-mir-10392/Upstream/4425246; hsa-let-7a-2/Downstream/753048;
Nearest TSS
ENST00000527297/Upstream/28329; ENST00000525558/Downstream/3569;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/79102, chr11-CpG: 170/Downstream/360527
Upstream sequence
CTCCTGCTCCTTTTGGATCATCCTGTGGCCTTTTTCTATCCCAGCTCCCAGCCAGCTGCCCCACCTCTTCCCCAGTCTCATTTATCCTTGTCCTCTGACC
Downstream sequence
CCAGCCACCATTTTGCACCATCCTCCCTGCCACTATCTCCTCCTACCTGCCGCCAGCCCCCACATCTACACCCATGTCGCCCTGCGCTCTCACTGTCCCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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