Fusion event
HPV-DLG2 integration
Detection method
PCR and Sanger sequencing
Quality evaluation
Perfect
Integrated sequence
GCAACAGTTACTGCGACGTGAGGTATATGACTTTGCTTTTCGGGATTTATGCATAGTATATAGAGATGGGAATCCATATGCTGTATGTGATAAATGTTTAAAGTTTTATTCTAAAATTAGTG
End
83452234/83741191 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10392/Upstream/1850355; hsa-let-7a-2/Downstream/2537142;
Downstream sequence
TGGCTGTGGGTTTGTCATAAATGTCTCTTATTATATTGAGGTTATGTTCCTTCAGTG
Junction sequence
TGACCCCAAAAAGTTTGGTTTTCCTGACACCTCATTTTATAATCCAGATACACAGCGGCTGGTTTGGGTCTGTGTAGGTGTTGAGGTAGGTCGTGGTCAGCCATTAGGTGTGGGCATTAGTGGCTGTGGGTTTGTCATAAATGTCTCTTATTATATTGAGGTTATGTTCCTTCAGTG
* Color:
Human Sequence
/
Virus Sequence
/
Overlapped sequence
/
Unknown sequence
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.