Basic Information
VIS ID
TVIS20003641
Fusion event
HPV-P3H2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Start
7115
End
7080
Orient
-
Integrated sequence
TTAGGAAAACGAAAAGCTACACCCACCACCTCATCT
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
189677772/189959983 (Hg38)
End
189677772/189959983 (Hg38)
Location type
Intronic
Target gene
P3H2
miRNAs that regulate target gene
hsa-mir-627-5p ; hsa-mir-3653-3p ; hsa-mir-570-3p ; hsa-mir-5197-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-7109-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-6740-5p ; hsa-mir-6867-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-891b ; hsa-mir-203b-3p ; hsa-mir-3689d ; hsa-mir-6825-5p ; hsa-mir-6851-5p ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-7854-3p
Nearest miRNA
hsa-let-7g/Upstream/129974; hsa-mir-3137/Downstream/5174523;
Nearest TSS
ENST00000440867/Upstream/170182; ENST00000412203/Downstream/4138;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1012220, chr3-CpG: 99/Downstream/160308
Downstream sequence
TTCCACAGGCTGATTGGGAAATGCGAATTGTATTCTAACTAGTGGAAAGTCATGTAGTCCCCACACCCCAAC
Junction sequence
GATGAGGTGGTGGGTGTAGCTTTTCGTTTTCCACAGGCTGATTGGGAAATGCGAATTGTATTCTAACTAGTGGAAAGTCATGTAGTCCCCACACCCCAAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate