Basic Information
VIS ID
TVIS20003663
Fusion event
HPV-DLG2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Start
443
End
346
Orient
-
Integrated sequence
AGTTTGTATGGAACAACATTAGAACAGCAATACAACAAACCGTTGTGTGATTTGTTAATTAGGTGTATTAACTGTCAAAAGCCACTGTGTCCTGAAGA
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
End
84402641/84691598 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10392/Upstream/2800762; hsa-let-7a-2/Downstream/1586735;
Upstream sequence
GGCCTTTGGGTATCAGTATTCATCAAAAACAATCATTTTTCTCACAT
Junction sequence
GGCCTTTGGGTATCAGTATTCATCAAAAACAATCATTTTTCTCACATCTGCAACAAGACATACATCGACCGGTCCACCGACTCCTTATATTATGGAATCTTTGCTTTTTGTCCAGATGTCTTTGCTTCTCTTCAGGCCACAGTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate