Basic Information
VIS ID
TVIS20003679
Fusion event
HPV-DLG2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Start
890654
End
890746
Orient
+
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
84452569/84741526 (Hg38)
End
84452569/84741526 (Hg38)
Location type
Intronic
Target gene
DLG2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10392/Upstream/2850690; hsa-let-7a-2/Downstream/1536807;
Nearest TSS
ENST00000527297/Upstream/20700; ENST00000532123/Downstream/181611;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1455033, chr11-CpG: 24/Downstream/886773
Upstream sequence
TTGGTTCTAGGTGGGTGTCATAGTTTAGTCTTTATGTGGTTTCTCCAGCTGTAATTCACACTAGTGATGTTTGTGAGTATCTCAGTGGTCTAGGCT
Junction sequence
TTGGTTCTAGGTGGGTGTCATAGTTTAGTCTTTATGTGGTTTCTCCAGCTGTAATTCACACTAGTGATGTTTGTGAGTATCTCAGTGGTCTAGGCTTGTAAATATTAAGTTGTATGTGTGTTTGTATGTATGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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