Basic Information
VIS ID
TVIS20003689
Fusion event
HPV-FHIT integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Start
135
End
177
Orient
+
Integrated sequence
GTTACCACAGTTATGCACAGAGCTGCAAACAACTATACATGAT
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
End
60373531/60387798 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/4535204; hsa-mir-12124/Downstream/230007;
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Downstream sequence
CAAACAAACCATAAGCAAACTATAGCCAAAATATTTCAGATGTGATTGTGGAAGATAAGGATGGTGTGTTTGAGGGTATAGTCGCTTCAAAGGCCTGT
Junction sequence
ATCCAGCGACCAAGATCAGAGCCAGACACCGGAAACCCCTGCCACAAACAAACCATAAGCAAACTATAGCCAAAATATTTCAGATGTGATTGTGGAAGATAAGGATGGTGTGTTTGAGGGTATAGTCGCTTCAAAGGCCTGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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