Basic Information
VIS ID
TVIS20003690
Fusion event
HPV-DLG2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV31
Reference genome
HQ537687.1
Start
1154
End
1089
Orient
-
Integrated sequence
GAACATGCAGAGGCTGTGCAGGTTCTAAAACGAAAGTATGTAGGTAGTCCTTTAAGTGATATTAGT
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
85004773/85293729 (Hg38)
End
85004773/85293729 (Hg38)
Location type
Intronic
Target gene
DLG2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10392/Upstream/3402893; hsa-let-7a-2/Downstream/984604;
Nearest TSS
ENST00000527297/Upstream/160606; ENST00000530901/Downstream/231293;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2007236, chr11-CpG: 24/Downstream/334570
Upstream sequence
ATCTAATGAGCAGTCCAAACTCATTTCAGCAGTTGTCTCCATAATGTCTTTTATAG
Junction sequence
ATCTAATGAGCAGTCCAAACTCATTTCAGCAGTTGTCTCCATAATGTCTTTTATAGGCAGACACAGCAGATGTGGACTGTACAGCAGTAGAAGGGGAAACATTATGTGTGGCAGGGGTATCC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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