Basic Information
VIS ID
TVIS20003706
Fusion event
HPV-POU5F1B integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
Start
6138
End
6083
Orient
-
Integrated sequence
ATTTTGGGCTGTGCCCCTGCTATTGGGGAACACTGGGCTAAAGGCACTGCTTGTAA
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
End
128225338/127213093 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12123/Upstream/2391035; hsa-mir-10400/Downstream/582869;
Downstream sequence
TCCCCTCTCCCAGACTGGGAGCCCCCTGAGGACAAGGGTGATGTTTCATTTATCACTAAGCTCTA
Junction sequence
GGCAATCGCCCTGTGATAAAGGACGCGATTTACAAGCAGTGCCTTTAGCCCAGTGTCCCCTCTCCCAGACTGGGAGCCCCCTGAGGACAAGGGTGATGTTTCATTTATCACTAAGCTCTA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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