Basic Information
VIS ID
TVIS20003742
Fusion event
HPV-KLF12 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Start
5465
End
5515
Orient
-
Integrated sequence
GTATCAGGTCCTGATATACCCATTAATATAACTGACCAAGCTCCTTCATTA
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
End
74230783/73656646 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-1297/Upstream/7438322; hsa-mir-1267/Downstream/4041366;
Upstream sequence
CACTCAGAGTTGGTTTTAGTTCTCCTCTGTTAGCAAAAAAAAGAAATATCTGCTCTTCAGCACTGTATT
Junction sequence
CACTCAGAGTTGGTTTTAGTTCTCCTCTGTTAGCAAAAAAAAGAAATATCTGCTCTTCAGCACTGTATTAGTATCAGGTCCTGATATCCCAATTAATATAACTGACCAAGCTCCTTCGTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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