Basic Information
VIS ID
TVIS20003752
Fusion event
HPV-ZNF681 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Start
1591
End
1616
Orient
-
Integrated sequence
TACACCCAGTATAGCTGACAGTATAA
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
23928815/23746013 (Hg38)
End
23928815/23746013 (Hg38)
Location type
Intronic
Target gene
ZNF681
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-298 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-519b-3p ; hsa-mir-519c-3p ; hsa-mir-519a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548h-3p ; hsa-mir-548z ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-665 ; hsa-mir-6771-5p ; hsa-mir-623 ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-6746-5p ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-5690 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-7160-5p ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-7977 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6514-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-3192-5p ; hsa-mir-7851-3p ; hsa-mir-490-3p
Nearest miRNA
hsa-mir-10395/Upstream/3346659; hsa-let-7e/Downstream/11376687;
Nearest TSS
ENST00000633603/Upstream/58793; ENST00000531821/Downstream/12824;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/274571, chr19-CpG: 21/Downstream/12425
Upstream sequence
TGCCTTTAAAAGTAAATTGCCAACTTCAATTATTTTGCATACAGCAGCACACCTGACAGTGGATAA
Junction sequence
TGCCTTTAAAAGTAAATTGCCAACTTCAATTATTTTGCATACAGCAGCACACCTGACAGTGGATAACTTACACCCAGTATAGCTGACAGTAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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