Basic Information
VIS ID
TVIS20003757
Fusion event
HPV-STK32B integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Start
1653
End
1689
Orient
-
Integrated sequence
TTCAAAGTTTAGCATGTTCATGGGGAATGGTTGTGTT
Host Sequence
Chromosome
chr4
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
5184435/5182708 (Hg38)
End
5184435/5182708 (Hg38)
Location type
Intronic
Target gene
STK32B
Nearest miRNA
hsa-mir-4800/Upstream/2932552; hsa-mir-12113/Downstream/740567;
Nearest TSS
ENST00000502981/Upstream/43072; ENST00000513705/Downstream/21371;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/130551, chr4-CpG: 18/Downstream/385700
Downstream sequence
CTCGGCCTCTCAACGTGCTGGGATTACAGATGTGAGCCACTGCG
Junction sequence
CACAACCATTCCCCATGAACATGCTAAACTTTGAATGCTCGGCCTCTCAACGTGCTGGGATTACAGATGTGAGCCACTGCG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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