Basic Information
VIS ID
TVIS20003763
Fusion event
HPV-C8orf34 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Start
7052
End
7122
Orient
-
Integrated sequence
AGGATTGAAGGCCAAACCAAAATTTACATTAGGAAAACGAAAAGCTACACCCACCACCTCATCTACCTCTA
Host Sequence
Chromosome
chr8
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
69630941/68718706 (Hg38)
End
69630941/68718706 (Hg38)
Location type
Intronic
Target gene
C8orf34
Nearest miRNA
hsa-mir-124-1/Upstream/4339449; hsa-mir-10400/Downstream/5829837;
Nearest TSS
ENST00000518652/Upstream/93247; ENST00000528286/Downstream/134057;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/387138, chr8-CpG: 224/Downstream/1113157
Upstream sequence
GCAGTGCTTAGCTACATCCAACTTTTTTCAGCCATTATTTTTACTTTTGCTGCTTGT
Junction sequence
GCAGTGCTTAGCTACATCCAACTTTTTTCAGCCATTATTTTTACTTTTGCTGCTTGTAGAGGTAGATGAGGTGGTGGGTGTAGCTTTTCGTTTTCCTAATGTAAATTTTGGTTTGGCCTTTAATCCTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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