Basic Information
VIS ID
TVIS20003766
Fusion event
HPV-TLN1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Start
5436
End
5520
Orient
-
Integrated sequence
CTTTTGGTGGTGCATACAATATTCCTTTAGTATCAGGTCCTGATATACCCATTAATATAACTGACCAAGCTCCTTCATTAATTCC
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
End
35722042/35722045 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-760 ; hsa-mir-92b-3p ; hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-222-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-let-7b-5p ; hsa-mir-218-5p ; hsa-mir-2681-5p ; hsa-mir-3682-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6827-3p ; hsa-mir-340-3p ; hsa-mir-3613-3p ; hsa-mir-4282 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-6827-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-544b ; hsa-mir-383-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-4293 ; hsa-mir-6821-5p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-561-5p ; hsa-mir-6830-5p ; hsa-mir-8080 ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-1229-5p ; hsa-mir-1275 ; hsa-mir-197-5p ; hsa-mir-3115 ; hsa-mir-3132 ; hsa-mir-4271 ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-4525 ; hsa-mir-4651 ; hsa-mir-4662a-3p ; hsa-mir-4665-5p ; hsa-mir-4723-5p ; hsa-mir-4725-3p ; hsa-mir-4731-5p ; hsa-mir-5010-5p ; hsa-mir-5698 ; hsa-mir-608 ; hsa-mir-625-5p ; hsa-mir-637 ; hsa-mir-6751-5p ; hsa-mir-6752-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6769a-3p ; hsa-mir-6780b-5p ; hsa-mir-6782-5p ; hsa-mir-6803-5p ; hsa-mir-6835-5p ; hsa-mir-6842-5p ; hsa-mir-6870-5p ; hsa-mir-7110-5p ; hsa-mir-7111-5p ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-101-2/Upstream/11304; hsa-let-7a-1/Downstream/10877;
Nearest CpG islands
Downstream sequence
TTGCCCTCAGTCACATCTCCCCCCATTCCCTAAGATTCCCATTCTCTTCCTTGC
Junction sequence
CCTTTTGGTGGTGCATACAATATTCCTTTAGTATCAGGTCCTGATATACCCATTAATATAACTGACCAAGCTCCTTCGTTACTTCCCTTGCCCTCAGTCACATCTCCCCCCATTCCCTAAGATTCCCATTCTCTTCCTTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate