Basic Information
VIS ID
TVIS20003772
Fusion event
HPV-SOX14 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Start
1240
End
1209
Orient
-
Integrated sequence
AAAAACAAAGTAGAGCTGCAAAAAGGAGATTA
Host Sequence
Chromosome
chr3
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
137466352/137747510 (Hg38)
End
137466352/137747510 (Hg38)
Location type
Intronic
Target gene
SOX14
Nearest miRNA
hsa-let-7g/Upstream/3309604; hsa-mir-1224/Downstream/13818366;
Nearest TSS
ENST00000440867/Upstream/765314; ENST00000306087/Downstream/16774;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/714669, chr3-CpG: 16/Downstream/13643
Downstream sequence
TTAAAGATGTCTAAATGGAGAGCATGTTTTTTGGATATGTGAAAATGGATTGGAGCTGTAAACA
Junction sequence
CCAAGATCACTGTGTGCCTCCTGGGGGAGGTTGTAGACCAAAATTAAAGATGTCTAAATGGAGAGCATGTTTTTTGGATATGTGAAAATGGATTGGAGCTGTAAACA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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