Basic Information
VIS ID
TVIS20003780
Fusion event
HPV-GJD3 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Start
2482
End
2527
Orient
-
Integrated sequence
GGATGGAAATTTAGTTTCTATGGATGTAAAGCATAGACCATTGGTA
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
End
38512014/40355762 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-510-3p ; hsa-mir-4474-3p ; hsa-mir-4738-3p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-2681-5p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-6732-5p ; hsa-mir-6856-5p ; hsa-mir-7153-3p ; hsa-mir-6758-5p ; hsa-mir-7159-5p ; hsa-mir-26b-3p ; hsa-mir-3065-5p ; hsa-mir-654-3p ; hsa-mir-580-5p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-505-3p ; hsa-mir-421 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-3182 ; hsa-mir-4680-3p ; hsa-mir-5187-3p ; hsa-mir-4427 ; hsa-mir-138-2-3p ; hsa-mir-4762-5p ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-4633-5p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-3065-3p ; hsa-mir-532-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-4284 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-6852-5p ; hsa-mir-6742-3p ; hsa-mir-939-3p ; hsa-mir-660-3p ; hsa-mir-6890-3p ; hsa-mir-3613-3p ; hsa-mir-4668-5p ; hsa-mir-629-3p ; hsa-mir-3692-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-2355-5p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-4755-3p ; hsa-mir-942-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-1236-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-877-3p ; hsa-mir-1273g-3p ; hsa-mir-181a-2-3p ; hsa-mir-6777-3p ; hsa-mir-4639-3p ; hsa-mir-382-3p ; hsa-mir-605-5p ; hsa-mir-24-3p ; hsa-mir-1972 ; hsa-mir-34b-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-383-3p ; hsa-mir-4690-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-498 ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-4279 ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6814-5p ; hsa-mir-4714-3p ; hsa-mir-5571-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-5009-3p ; hsa-mir-512-3p ; hsa-mir-552-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-4632-3p
Nearest miRNA
hsa-mir-1180/Upstream/162099; hsa-mir-10226/Downstream/1161402;
Upstream sequence
GCTGGTGGCATGGGGCAAGTGGTCCCGAACTCCGGCTCCAGGGCCAGACTGCCGGCCTGGGCTAGACGCCAAGCCCTT
Junction sequence
GCTGGTGGCATGGGGCAAGTGGTCCCGAACTCCGGCTCCAGGGCCAGACTGCCGGCCTGGGCTAGACGCCAAGCCCTTATATGCCAATGGTCTATGCTTTACATCCATAGAAACTAAATTTCCATCCAATGCATTTCTTAAATTGTCATCTATGTAGTTCCAACGGGCACTGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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