Basic Information
VIS ID
TVIS20003796
Fusion event
HPV-MAPK10 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Start
791
End
732
Orient
-
Integrated sequence
TGTTGCAAGTGTGACTCTACGCTTCGGTTGTGCGTACAAAGCACACACGTAGACATTCGT
Host Sequence
Chromosome
chr4
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87136562/86215409 (Hg38)
End
87136562/86215409 (Hg38)
Location type
Intronic
Target gene
MAPK10
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-5002-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-3152-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-mir-12113/Upstream/492876; hsa-mir-1243/Downstream/327073;
Nearest TSS
ENST00000502981/Upstream/44337; ENST00000507902/Downstream/53160;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/739593, chr4-CpG: 77/Downstream/378621
Nearest cancer related gene
MAPK10(TSG, No orient, 0)
Downstream sequence
AATTTGTCTATTTTTGCTTTTGTTGCTTGTG
Junction sequence
GGGCGTCAGAGGTAACCATAGAACCACTAGGTGTAGGAAAATAATTTGAACTGGCTAAATTTGTCTATTTTTGCTTTTGTTGCTTGTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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