VISDB Viral Integration Site DataBase

VIS ID

TVIS20003813

Fusion event

HPV-DIAPH2 integration

Validated

Yes

Detection method

APOT and sequencing

Data source

Curated

Sample type

Disease

Head and neck squamous cell carcinoma (HNSCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Gene

E2

Start

3105

Integrated sequence

ATCCACAACATTACTGGCGTGCTTTTTGCTTTGCTTTTGTGTGCTTTTGTGTGTCTGCCTATTAATACGTCCGCTGCTTTTGTCTGTGTCTACATACACA| |TCATTAATAATATTGGTATTACTATTGTGGATAACAGCAGCCTCTGCGTTTAGGTGTTTTATTGTATATATTATATTTGTTTATATACCATTATTTTTAA

Chromosome

chrX

Cytoband

q21.33

Reference genome

Start

End

96369882/97114883 (Hg38)

Orient

-

Location type

Exon

Target gene

miRNAs that regulate target gene

hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p

Nearest miRNA

hsa-let-7f-2/Upstream/2051657; hsa-mir-105-1/Downstream/9524931;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/429516, chrX-CpG: 23/Downstream/2824453

Upstream sequence

CATTAAATGTATATTCTCATAGGGTATTTCTTATCTTACAGATGAGCTCTGTGAAAATGTTACAGCCTCGTCTCAGTAGTATCCTGTTCAAGCTCACATT

Downstream sequence

AGTTCTTCTTGTTGGAAACTACATGAACTCAGGCTCAAGAAATGCCCAGTCTTTGGGATTTAAGATCAACTTCCTTTGTAAGGTAAGATGACATTTTATA

Target sequence

TGAAGAACACATAAACAACATCAAACCAAGCATCATAGCAGTAACTCTTGCCTGTGAAGAACTGAAGAAAAGTGAAAGCTTTAACAGACTTTTAGAGTT