CDH13 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20003819
Fusion event
HPV-CDH13 integration
Validated
Yes
Fusion type
Insert
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Nontumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27759101
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E7
Start
1226
Integrated sequence
TACAGGTTC TAAAACGAAAGTATTTGGTAGTCCACTTAGTGATATTAGTGGATGTGTAGACAATAATATTAGTCCTAGA TTAAAAGCTATATGTATAG| |AAAAACAAAGTAGAGCTGCAAAAAGGAGATTATTTGAAAGCGAAGACAGCG GGTATGGCAATACTGAAGTGGAAACTCAGCAGATGTTACAGGTAGAAG
Host Sequence
Chromosome
chr16
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
83557291/83523686 (Hg38)
End
83557291/83523686 (Hg38)
Location type
Intron8
Target gene
CDH13
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-181a-5p ; hsa-mir-4464 ; hsa-mir-4307 ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-31-3p ; hsa-mir-367-5p ; hsa-mir-1266-3p
Nearest miRNA
hsa-mir-1225/Upstream/15278; hsa-mir-11401/Downstream/1684110;
Nearest TSS
ENST00000527434/Upstream/125516; ENST00000562307/Downstream/131134;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/895478, chr16-CpG: 67/Downstream/284121
Nearby gene
CDH13
Nearest cancer related gene
CDH13(TSG, No orient, 0)
Upstream sequence
GCAACCGGATATGCCCACTGAGGTGGAATCTGAGC
Junction sequence
GCAACCGGATATGCCCACTGAGGTGGAATCTGAGCTCTACTTTGTTTTTCTATACATATAGCTTTTAATCTAGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Liu, Y., et al. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology. Sci Rep,2016, 6: 35427.
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