Basic Information
VIS ID
TVIS20003824
Fusion event
HPV-chr5:q11.2 integration
Validated
Yes
Fusion type
Insert
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27759101
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E1
Start
2722
Integrated sequence
GGTG GCCTTATTTACATAATAGATTGGTGGTGTTTACATTTCCTAATGAGTTTCCATTTGACGAAAACGGAAAT CCAGTGTATGAGCTTAATGATAAG| |AACTGGAAATCCTTTTTCTCAAGGACGTGGTCCAGATTAAGTTTGC ACGAGGACGAGGACAAGGAAAACGATGGAGACTCTTTGCCAACGTTTAAATGT
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
51915461/52619627 (Hg38)
End
51915461/52619627 (Hg38)
Fragile sites / regions
FRA5H
Nearest miRNA
hsa-mir-10397/Upstream/14062066; hsa-mir-103a-1/Downstream/1331877;
Nearest TSS
ENST00000502646/Upstream/609812; ENST00000506949/Downstream/168269;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1220109, chr5-CpG: 34/Downstream/168485
Upstream sequence
AGCTAGAGACTGTTCATGTCAGAGATCAGG
Junction sequence
AGCTAGAGACTGTTCATGTCAGAGATCAGGAATCTGGACCACGTCCTTGAGAAAAAGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Liu, Y., et al. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology. Sci Rep,2016, 6: 35427.
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