Basic Information
VIS ID
TVIS20003825
Fusion event
HPV-PPP6R3 integration
Validated
Yes
Fusion type
Insert
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27759101
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E7
Start
1457
Integrated sequence
AGTATAGTGGTGGAAGTGGGGGTGGTTGCAGTCAGTACAGTAGTGGAAGTGGGGGAGAGGGT GTTAGTGAAAGACACACTATATGCCAAACACCACTTA| |CAAATATTTTAAATGTACTAAAAACTAGTAATG CAAAGGCAGCAATGTTAGCAAAATTTAAAGAGTTATACGGGGTGAGTTTTTCAGAATTAGTAAGAC
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68274085/68506617 (Hg38)
End
68274085/68506617 (Hg38)
Location type
Intron1
Fragile sites / regions
FRA11H ; FRA11A
Target gene
PPP6R3
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-615-3p ; hsa-mir-20a-5p ; hsa-mir-624-3p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-552-5p ; hsa-mir-652-5p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548t-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548ao-5p ; hsa-mir-548ax ; hsa-mir-548az-5p ; hsa-mir-7854-3p ; hsa-mir-759 ; hsa-mir-3174 ; hsa-mir-3678-3p ; hsa-mir-3944-5p ; hsa-mir-4519 ; hsa-mir-2467-3p ; hsa-mir-5586-3p ; hsa-mir-1273h-3p ; hsa-mir-623 ; hsa-mir-542-3p ; hsa-mir-107 ; hsa-mir-1909-5p ; hsa-mir-2277-3p ; hsa-mir-6780b-3p ; hsa-mir-6841-3p ; hsa-mir-4780 ; hsa-mir-5190 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4696 ; hsa-mir-5585-5p ; hsa-mir-32-3p ; hsa-mir-548n ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-424-5p ; hsa-mir-4264 ; hsa-mir-4291 ; hsa-mir-4704-3p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10392/Upstream/461660; hsa-let-7a-2/Downstream/576559;
Nearest TSS
ENST00000527297/Upstream/45804; ENST00000531244/Downstream/12889;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/45509, chr11-CpG: 28/Downstream/163554
Nearby gene
PPP6R3
Upstream sequence
TTGGAAATTCTCTTTGTGATTTTGAAATGC
Junction sequence
TTGGAAATTCTCTTTGTGATTTTGAAATGCTAGTACATTTAAAATATTTGTAAGTGGTGTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Liu, Y., et al. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology. Sci Rep,2016, 6: 35427.
Curate