Basic Information
VIS ID
TVIS20003826
Fusion event
HPV-LOC105373815 integration
Validated
Yes
Fusion type
Insert
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27759101
Virus Sequence
Virus name
HPV
Subtype
HPV33
Reference genome
M12732.1
Gene
E7
Start
3088
Integrated sequence
ACATTAAGTAAATCACAGTATAGTACAAGCCAATGGACATTGCAACAAACAAGCTTAGAGGTGTGGCTTTGTGAACCACCAAAATGTTTTAAAAAACAAG| |GAGAAACAGTAACTGTGCAATATGACAATGACAAAAAAAATACAATGGATTATACAAACTGGGGTGAAATATATATTATAGAGGAAGATACATGTACTAT
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
194815184/193950460 (Hg38)
End
194815184/193950460 (Hg38)
Location type
Intronic
Target gene
LOC105373815
Nearest miRNA
hsa-mir-10b/Upstream/4817349; hsa-mir-1244-1/Downstream/12832774;
Nearest TSS
ENST00000437798/Upstream/52093; ENST00000438505/Downstream/393809;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1754374, chr2-CpG: 150/Downstream/1706371
Upstream sequence
TTTTGAAATGTTAATCCAAGAGTCATACT
Junction sequence
TTTTGAAATGTTAATCCAAGAGTCATACTCTTGTTTTTTAAAACATTTTGGTGGTTCACAAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Liu, Y., et al. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology. Sci Rep,2016, 6: 35427.
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