Basic Information
VIS ID
TVIS20003827
Fusion event
HPV-CCNY integration
Validated
Yes
Fusion type
Insert
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27759101
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E6
Start
4329
Integrated sequence
TTTTCATATATAATTTTTTTTTTTGTTTGT TTGTTTGTTTTTTAATAAACTGTTATTACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAAC| |G TGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAG GTTGAAGGCAAAACTATTGCTGAACAA
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
35576491/35287563 (Hg38)
End
35576491/35287563 (Hg38)
Location type
Intron3
Target gene
CCNY
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-193b-3p ; hsa-mir-4669 ; hsa-mir-6516-5p ; hsa-mir-6751-5p ; hsa-mir-6803-5p ; hsa-mir-455-3p ; hsa-mir-4497 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6499-3p ; hsa-mir-6835-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-4795-5p ; hsa-mir-1296-3p ; hsa-mir-298 ; hsa-mir-4696 ; hsa-mir-1252-5p ; hsa-mir-186-3p ; hsa-mir-922 ; hsa-mir-4733-5p ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-1265/Upstream/207883; hsa-mir-107/Downstream/353609;
Nearest TSS
ENST00000439456/Upstream/40514; ENST00000470025/Downstream/33435;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/72470, chr10-CpG: 141/Downstream/48558
Nearby gene
CCNY
Upstream sequence
TTTTCTTTCCGTATTAATTTTGCCTGTTCTAGAATT
Junction sequence
TTTTCTTTCCGTATTAATTTTGCCTGTTCTAGAATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Liu, Y., et al. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology. Sci Rep,2016, 6: 35427.
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