Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene41821768417546044178693141717742417346444173752441741225417333724173538041762709417642684176861941769893417608874176168141769755
Basic Information
VIS ID
TVIS20003828
Fusion event
HPV-JUP integration
Validated
Yes
Fusion type
Insert
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical intraepithelial neoplasia (CIN)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27759101
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E1
Start
1688
Integrated sequence
ATTGGTGTATTGCTGCATTTGGACTTACACCCAGTATAGCTGAC AGTATAAAAACACTATTACAACAATATTGTTTATATTTACACATTCAAAGTTTAG| |CATGTTCATGGGGAA TGGTTGTGTTACTATTAGTAAGATATAAATGTGGAAAAAATAGAGAAACAATTGAAAAATTGCTGTCTAA ACTATTATGTGTG
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
39926007/41769755 (Hg38)
End
39926007/41769755 (Hg38)
Location type
Intron2
Target gene
JUP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-615-3p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-1180/Upstream/252538; hsa-mir-10226/Downstream/725018;
Nearest TSS
ENST00000595228/Upstream/6678; ENST00000429461/Downstream/2514;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/11981, chr17-CpG: 74/Downstream/16468
Nearby gene
JUP
Nearest cancer related gene
JUP(OG, No orient, 0)
Upstream sequence
ACTGGGGAGCAGGGCAGGCCACAGACAG
Junction sequence
ACTGGGGAGCAGGGCAGGCCACAGACAGTCCACAACCATTCCCCATGAACATGCTAAACTTTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Liu, Y., et al. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology. Sci Rep,2016, 6: 35427.
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