Basic Information
VIS ID
TVIS20003839
Fusion event
HPV-ASIC2 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV35
Reference genome
Not given
Gene
E7
Start
686
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
32146599/33819580 (Hg38)
End
32146599/33819580 (Hg38)
Location type
Intron1
Target gene
ASIC2
Nearest miRNA
hsa-mir-1180/Upstream/1469378; hsa-mir-10226/Downstream/3214165;
Nearest TSS
ENST00000595228/Upstream/2819; ENST00000582685/Downstream/14987;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/526133, chr17-CpG: 46/Downstream/220344
Upstream sequence
TCCTAGAAGAAGAAATAATTGGAATAAGGAAATGAAAGCCCTGGTTAAGACCAACACATTTCCCttttctttttttttttttttttttttttAACAACAA
Downstream sequence
GACAGGTGGAGCTAAGTGCAACATCAGGGATCATTGCAGTTTGGGAAATTCTAATGCTGAGACTGTGACCTTGGCCATGCCAGAGGATCTCCGGCAGAGT
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate