Basic Information
VIS ID
TVIS20003845
Fusion event
HPV-chr9:q31.3 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E6
Start
2721
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
End
111540963/108778683 (Hg38)
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-let-7a-1/Upstream/2177661; hsa-mir-12126/Downstream/267546;
Nearby gene
ACTL7B(+75905) ;
Upstream sequence
TACGGAAAAAGCTGGCTGTTGTTGTGTCTTTAAAGTTTCACCTGGGTAGTCAAAGATGGATCATGGGTCTCAGTGGAGAGCTGAGCCAGGCAGGAGCTGA
Downstream sequence
CCAGAGACTTTCAGAGACAGAAAAGGGCAAGAGTGGGAAACAAGGAGGGCAGTGAAAAGGGCCCATAACCTACCTTCACCAGGAAGAAGGAGACACCGTA
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
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