BIRC3 _HNSC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20003863
Fusion event
HPV-BIRC3 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E6
Start
3353
Host Sequence
Chromosome
chr11
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
102201771/102331040 (Hg38)
End
102201771/102331040 (Hg38)
Location type
Exon7
Target gene
BIRC3
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-375 ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-10392/Upstream/811135; hsa-let-7a-2/Downstream/1518866;
Nearest TSS
ENST00000527297/Upstream/5819; ENST00000527336/Downstream/5481;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/13331, chr11-CpG: 83/Downstream/15803
Nearest cancer related gene
BIRC3(OG, No orient, 0)
Upstream sequence
ACATGCAAACCACTGGGAGGAGTGCGGAACGCCTGGTACAGATAGGGGTGGGGATTTGGGTGACGCATTTAAAAGACAGCGTGAGACTCGCGCCCTCCGG
Downstream sequence
CACGGAAAAGGCCAGGCGACAGGTGTCGCTTGAAAAGACTGGGCTTGTCCTTGCTGGTGCATGCGTCGTCGGCCTCTGGGCAGCAGGTGGGCAAGGAAGG
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
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