Basic Information
VIS ID
TVIS20003873
Fusion event
HPV-DGLUCY integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E6
Start
522
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
91636219/91169875 (Hg38)
End
91636219/91169875 (Hg38)
Location type
Exon7
Target gene
DGLUCY
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1260a/Upstream/13903585; hsa-mir-1185-1/Downstream/2778351;
Nearest TSS
ENST00000550708/Upstream/9534; ENST00000520130/Downstream/166;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/108667, chr14-CpG: 87/Downstream/63862
Upstream sequence
AGGGTAGGATGTGATGTGGTATGTGAAGCTATGTGAGGCTGAATCTGCTGCCTTCAGGGGGCCACACTTTCTAATTTGTTCCCTTTCCTTCCCTCACCCA
Downstream sequence
CCTGGTGCCAGGGCTGAAAATTTCAGCACTAGACATCCTCTTCTCTCTCCGCAGTCCTTCTATAATGTATTATCAGGGGCCACAGTGAGAGTCTGGGGCC
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
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