Basic Information
VIS ID
TVIS20003876
Fusion event
HPV-DHRS4-AS1 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV35
Reference genome
Not given
Gene
L1
Start
861
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
24410029/23940820 (Hg38)
End
24410029/23940820 (Hg38)
Location type
Exon3
Target gene
DHRS4-AS1
Nearest miRNA
hsa-mir-208a/Upstream/522757; hsa-mir-1185-1/Downstream/202669;
Nearest TSS
ENST00000550708/Upstream/6252; ENST00000543741/Downstream/12549;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/363102, chr14-CpG: 32/Downstream/12741
Upstream sequence
TTACTGTTGATGCTTCAAAAGGgtgtgtgtgtgtgtgtgtgtgtTCAGTTAATCCAGAAATTCCTCCCAGGAAAATAGAAGACCCCAGGAGGAGTGGGGC
Downstream sequence
GGGCAGACAGATCTTCATGAAAACACACATGAACCTCCAGAACTCGATGTGCTCCACCAGCCGGCCTTAGCTTGTCAAAGCCAACCTTGGAATTTCCTGC
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate