Basic Information
VIS ID
TVIS20003878
Fusion event
HPV-chr15:q26.1 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E7
Start
841
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
90359792/89816560 (Hg38)
End
90359792/89816560 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/448454; hsa-mir-1302-10/Downstream/34077;
Nearest TSS
ENST00000557528/Upstream/1159; ENST00000559419/Downstream/21394;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/1219, chr15-CpG: 52/Downstream/77233
Nearby gene
ARPIN-AP3S2(+14038) ;
Upstream sequence
GTGCGATGATTGTGCACACGGCTGCCACGCCCAGGAGGATCCCCAGGATGCCCAGGGACTTGGAAATATAGAAGCCCTTGGCCATGGTGATGGTGGGGAG
Downstream sequence
tgtgagtgagacctcagaggctattttgtTTTTTTTCTCTCTCCAGTCTCATGCATGTCTGACTCTCTCCACTATCATATCTGGCATAATCTCCTCCATG
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate