Basic Information
VIS ID
TVIS20003922
Fusion event
HPV-chr11:q13.3 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E1
Start
619
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69624574/69809806 (Hg38)
End
69624574/69809806 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA11H ; FRA11A
Nearest miRNA
hsa-mir-10392/Upstream/726548; hsa-let-7a-2/Downstream/474149;
Nearest TSS
ENST00000527297/Upstream/34403; ENST00000534086/Downstream/7744;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/34028, chr11-CpG: 32/Downstream/534
Nearby gene
FGF3(+161) ;
Nearest cancer related gene
FGF3(OG, +161) ;
Upstream sequence
GAAGAATAGAATGGCACTTTTTCAACATTTGACTTGTGTAATTCCAATCCTGGATAGTCTACTAACTGCCGGAATTATTAATGAACAAGAACATGATGTT
Downstream sequence
ATTAAACAGAAGACACAGACGTCTTTACAAGCAAGAGAACTGATTGATACGATTTTAGTAAAAGGAAATATTGCAGCCACTGTATTCAGAAACTCTCTGC
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate