Basic Information
VIS ID
TVIS20003971
Fusion event
HPV-chr13:q22.1 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E7
Start
533
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
73619738/73045600 (Hg38)
End
73619738/73045600 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/6827276; hsa-mir-1267/Downstream/4652412;
Nearest TSS
ENST00000623511/Upstream/75961; ENST00000476859/Downstream/9376;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/263126, chr13-CpG: 163/Downstream/13122
Nearby gene
KLF5(-13403) ;
Nearest cancer related gene
KLF5(OG, -13403) ;
Upstream sequence
TACAACTGTAGCCTTTCTTTGAGTCACAAATTAAAAAGAATTTTATCTGGAATCAGATTTATTTATTCTTCAAATTTACTTCACTAGTTACTAAGAGGCC
Downstream sequence
TTTTCTCAACATTCTTCAAGGGTCCTTACAAATGAGTGTCAACAATGGGAAAGTGTTATTTTCgtgtaaccctggataagtcatttagcagccctggatt
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate